proinflammatory – Communicable Diseases Research

Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals

Article

Published on 2023-02-012023-07-11
Journal: Brain, behavior, and immunity
[Category] COVID19(2023년),

Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Article

Published on 2023-01-302022-11-15
Journal: Journal of ethnopharmacology
[Category] 유전자 메커니즘, 진단,

[키워드] Activation acute lung injury ALI model alleviate Analysis analysis attenuate Baidu caused Cell cellular China component Component analysis components Compound COVID-19 COVID-19 patients demonstrated experiment experimental validation Formula in vivo increases in indicated Inflammation ingredient inhibited inhibiting Kyoto lung Lung injury material mechanism of action Mild molecular mechanism network network pharmacology NF-κB pathway NF-κB signaling NF-κB signaling pathway Obstructive Ontology p-NF-κB p65 pathway pharmacological predicted proinflammatory Proteins reduced syndrome target treat Treatment Xuanfei baidu formula.
[DOI] 10.1016/j.jep.2022.115833 PMC 바로가기

Potential mechanisms of vaccine-induced thrombosis

Article

Published on 2022-11-012022-11-15
Journal: European journal of internal medicine
[Category] 유전자 메커니즘, 진단,

[키워드] activate Ad26.COV2.S Adenovirus administration AdV vector antibodies antibody Autoimmune heparin-induced thrombocytopenia B cell Bacteria BNT162b cerebral venous sinuse ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine characterized clinical conformational change Contact COVID-19 COVID-19 vaccine COVID-19 vaccines described develop Effectiveness elicited events expression Factors Gene therapy heparin-induced thrombocytopenia hexone immune complex immune response Immune thrombocytopenia immunothrombosis IMPROVE induce intrinsic knowledge laboratory feature mechanism monocyte occur PF4 Platelet Platelets Potential proinflammatory Protein receiving resulting Spike protein splice subject syndrome T-cell thrombosis Vaccine Vaccine- induced immune thrombocytopenia and thrombosis. vectors Venous thrombosis viruses
[DOI] 10.1016/j.ejim.2022.08.002 PMC 바로가기

Association of Interleukin-17F Polymorphism and Mortality Predictors with the Risk of COVID-19

Article

Published on 2022-10-272022-11-15
Journal: International journal of clinical practice
[Category] 변종, 진단,

[키워드] age allele Analysis association AUC case-control study CD4 cells Characteristics control subject controls Coronavirus disease-19 COVID-19 COVID-19 infection COVID-19 mortality COVID-19 patient COVID-19 patients cutoff point D-dimer death determine enzyme-linked immunosorbent exhibiting expression Genotype genotyping healthy higher odd hypertension IL-17 immunological injuries in-hospital mortality independent predictor investigated Laboratory no significant difference non-survivor outcome participant polymorphism predictor proinflammatory risk of COVID-19 ROC Curve subset suggested survivor susceptibility T lymphocytes tested variant WBC White blood cell with COVID-19
[DOI] 10.1155/2022/4761631 PMC 바로가기

Advances in Biosensing Technologies for Diagnosis of COVID-19

Article

Published on 2022-10-202022-11-15
Journal: Biosensors
[Category] COVID19(2023년), SARS, 치료기술,

Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled Trial

Article

Published on 2022-10-062022-11-15
Journal: The Journal of Nutrition
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] adhesion molecules age anti-inflammatory effect Antigen assigned baseline Biomarker Blood BMI C-reactive protein CDC chronic condition coin toss Concentration conducted Controlled coronavirus disease covariates COVID-19 COVID-19 complications COVID-19, SARS-COV-2 Cytokines diagnosed with COVID-19 Diagnosis dietary supplements double-blind dysregulated immune response Effect exacerbate ferritin group Health IL-1β IL-2 IL-6 implicated indicated individual infected with COVID-19 infections infectious conditions Inflammation inflammatory mediator intercellular Linear regression model mechanism Multiple outcomes P-selectin palmitoylethanolamide palmitoylethanolamide. participant Placebo placebo tablet positive test result Primary outcome produced proinflammatory promote randomized placebo-controlled trial Randomly receive reduced reported RT-PCR secretion severity Sex significantly stratified treatment effect
[DOI] 10.1093/jn/nxac154 PMC 바로가기

Single-Cell Gene Expression Analysis Revealed Immune Cell Signatures of Delta COVID-19

Article

Published on 2022-09-212022-11-16
Journal: Cells
[Category] SARS, 변종, 유전자 메커니즘,

[키워드] accompanied accompany adaptive B.1.617 Blood caused Characteristics contribute coronavirus disease correlated COVID-19 COVID-19 pathogenesis Cytokine storm Delta delta variant diagnostic dominant Factor Gene Expression gene expression signature high mortality highlight immune immune component immune response immune system Immunity immunological individual Infection Lineage lymphoid molecular monocyte Monocytes mononuclear cell Multiple myeloid cells pathway performed proinflammatory required Revealed risk SARS-CoV-2 SARS-CoV-2 lineage severity signature significant changes in single-cell syndrome targeted therapy therapeutic Transcriptome Transcriptome. understanding variant virus with COVID-19
[DOI] 10.3390/cells11192950 PMC 바로가기

Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern

Article

Published on 2022-09-162022-11-16
Journal: Science Advances
[Category] SARS, 변종, 유전자 메커니즘,

Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19

Article

Published on 2022-09-142022-11-15
Journal: Journal of Virology
[Category] SARS, 치료기술, 치료제,

[키워드] Activation amplified amplify analyzed blocked Blood Cell chemokine chronic liver disease Chronic Liver Diseases circulating comorbid disease Comorbidity contribute controls correlated COVID-19 COVID-19 patients Critical cytokine cytokine secretion DCLK1 DDCLK1 decrease disease severity dysregulation expression Factor Factors Gain growth factor hospitalized patient Host Hyperinflammatory response immune Immune cell immune response immunosuppressive in viral in vitro infected cells Inflammation Inflammatory cytokine inflammatory pathway inhibition inhibitor Innate immunity involved kinase Live virus liver livers loss of function lung Lung disease Macrophage mononuclear cell mononuclear cells Mortality neutrophil normalized Pathogenesis pathology Patient Peripheral blood potential therapeutic target Prevalence pro-inflammatory profile proinflammatory promoted promoter Protein S100A9 SARS-CoV-2 SARS-CoV-2-infected cell secretion severity of COVID-19 Signaling subject targeting Treatment Viremia virus production virus replication Virus replication. with COVID-19 β-catenin
[DOI] 10.1128/jvi.00967-22 PMC 바로가기

PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu

Article

Published on 2022-09-082022-11-15
Journal: Frontiers in Immunology
[Category] 바이오마커,

[키워드] accumulated CD4 Cell characterized co-stimulatory receptor COVID Critical Express expressed flu fluorescent FOXP3 GFP heterogenous human population iCoS IL-10 Immune homeostasis immunopathology in vivo Infection infections Influenza influenza infection influenza infections labeling lung tissue memory T cells molecular feature PD-1 proinflammatory promote Regulatory Regulatory T cell repeated reporter respiratory infectious disease response reveal secondary infections shown Signaling signaling pathway suppress T cell T cell response T cells tissue tissue repair tissue resident T cells. transcription factor Treg Treg cell Treg cells Tuberculosis
[DOI] 10.3389/fimmu.2022.984476 PMC 바로가기